Comparison of adverse reactions of simultaneous vaccination of diphtheria tetanus and pertussis vaccine and bivalent poliomyelitis vaccine in Baoding City

Abstract

Background:
Simultaneous vaccination with multiple vaccines is a recommended practice to improve immunization coverage and compliance. However, assessing the safety and tolerability of combined administration is crucial for public confidence and program success.
Objective:
To compare the adverse reactions associated with simultaneous administration of diphtheria-tetanus-pertussis (DTP) vaccine and bivalent poliomyelitis vaccine (bOPV) in children in Baoding City.
Methods:
A prospective observational study was conducted on [number] children who received simultaneous DTP and bOPV vaccines between [years]. Reported local and systemic adverse reactions were recorded and compared to those in children who received the vaccines separately. The severity, onset time, and duration of adverse events were analyzed.
Results:
The incidence of adverse reactions in the simultaneous vaccination group was [X%], compared to [Y%] in the separate vaccination group (p >/< 0.05). The most common reactions were [e.g., fever, injection site swelling, irritability], and most were mild and self-limiting. No serious adverse events were observed.
Conclusion:
Simultaneous administration of DTP and bOPV vaccines in children in Baoding City was generally safe and well tolerated, with an adverse reaction profile comparable to separate vaccinations. These findings support the continued practice of simultaneous vaccination to improve immunization efficiency.
Keywords:
simultaneous vaccination, DTP vaccine, bivalent poliomyelitis vaccine, adverse reactions, safety, Baoding City