Investigation of one case with osteomyelitis caused by coupling Staphylococcus aureus infection following vaccination

Abstract

Background:
Osteomyelitis is a rare but serious infection of bone, occasionally associated with invasive procedures or trauma. Cases of osteomyelitis following vaccination are extremely rare and merit investigation to understand potential causality.
Objective:
To report and analyze a rare case of osteomyelitis caused by Staphylococcus aureus infection after vaccination, exploring possible mechanisms and clinical management.
Methods:
A [age]-year-old [male/female] developed localized pain, swelling, and fever [X] days after receiving [name of vaccine] in the [site of injection]. Clinical examination, imaging studies, and laboratory tests confirmed the diagnosis of osteomyelitis with S. aureus isolated from [blood/bone aspirate]. The case was managed with [surgical debridement/antibiotic therapy] and monitored for recovery.
Results:
The patient presented with acute osteomyelitis at the injection site region. Microbiological testing identified methicillin-sensitive/resistant S. aureus as the causative pathogen. The infection responded to [specific antibiotics] with gradual clinical improvement and full recovery. No direct causal link between the vaccine itself and osteomyelitis could be established, but local tissue injury and secondary infection were considered likely contributing factors.
Conclusion:
This rare case highlights the need for vigilance regarding injection site infections and prompt diagnosis and management of osteomyelitis when symptoms occur after vaccination. Maintaining strict aseptic technique during vaccination is essential to minimize such risks.
Keywords:
osteomyelitis, Staphylococcus aureus, vaccination, adverse event, case report