Significance of detecting T lymphocyte subsets,serum CRP,TNF-α, and INF-γ in pulmonary tuberculosis patients

Abstract

Objective: To evaluate the clinical significance of detecting T lymphocyte subsets, serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (INF-γ) levels in patients with pulmonary tuberculosis (TB).
Methods: A cohort of pulmonary TB patients was assessed for peripheral blood T lymphocyte subsets (CD4+, CD8+), and serum levels of CRP, TNF-α, and INF-γ. Correlations between these immune and inflammatory markers and disease severity were analyzed.
Results: Pulmonary TB patients exhibited significant alterations in T lymphocyte subsets, characterized by decreased CD4+ counts and altered CD4+/CD8+ ratios. Serum CRP and TNF-α levels were elevated, reflecting systemic inflammation, while INF-γ levels correlated with immune activation against Mycobacterium tuberculosis. These markers were associated with disease activity and treatment response.
Conclusion: Detection of T lymphocyte subsets and serum CRP, TNF-α, and INF-γ provides valuable insights into the immune status and inflammatory response in pulmonary TB patients. These biomarkers can aid in disease monitoring, prognosis evaluation, and guiding therapeutic strategies.