Gene mutation analysis of Plasmodium falciparum infection cases imported from abroad in Fuzhou City

Abstract

Objective: To investigate the gene mutation patterns of Plasmodium falciparum strains in imported malaria cases in Fuzhou City, aiming to monitor drug resistance and guide treatment strategies.
Methods: Blood samples from patients diagnosed with P. falciparum malaria imported from abroad were collected in Fuzhou City. Molecular analysis was conducted to detect mutations in key genes associated with antimalarial drug resistance, including pfcrt, pfmdr1, pfdhfr, and pfdhps. Mutation frequencies and patterns were analyzed to assess the prevalence of resistance markers.
Results: Multiple mutations related to chloroquine, sulfadoxine-pyrimethamine, and artemisinin resistance were identified among the imported P. falciparum isolates. The prevalence of mutations in pfcrt and pfmdr1 genes was notably high, indicating potential reduced susceptibility to standard antimalarial drugs. Continuous monitoring is essential to detect emerging resistance trends.
Conclusion: Gene mutation analysis of P. falciparum strains imported into Fuzhou City reveals significant drug resistance markers. These findings highlight the importance of molecular surveillance to inform effective malaria treatment and control policies.