Study on assisting blood lipids reduction function of compound soybean phospholipid soft capsule in rats

Abstract

Objective:
To evaluate the effect of compound soybean phospholipid soft capsules on reducing blood lipid levels in rats with hyperlipidemia and explore its potential as a lipid-lowering agent.
Methods:
A hyperlipidemia rat model was established by feeding rats a high-fat diet. Rats were randomly divided into control, model, and treatment groups. The treatment group received compound soybean phospholipid soft capsules at different doses by gavage for a specified period. Serum levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured. Liver histopathology was also examined.
Results:
Compared to the model group, the treatment groups showed significant reductions in serum TC, TG, and LDL-C levels (p < 0.05), while HDL-C levels increased. Histopathological analysis revealed improved hepatic steatosis and reduced lipid deposition in the liver tissue of treated rats.
Conclusion:
Compound soybean phospholipid soft capsules effectively lower blood lipid levels and improve lipid metabolism in hyperlipidemic rats, suggesting their potential as a supportive therapy for managing hyperlipidemia.