Serological investigation and analysis of TORCH infection in women of childbearing age in Wuhu Area

Abstract

Objective:
To investigate the seroprevalence of TORCH infections — Toxoplasma gondii (TOX), rubella virus (RV), cytomegalovirus (CMV), and herpes simplex virus (HSV) — in women of childbearing age in the Wuhu area, and to provide a scientific basis for prevention and control of adverse pregnancy outcomes related to TORCH.
Methods:
A total of XXX women of childbearing age attending hospitals or health examination centers in Wuhu were enrolled. Serum samples were tested for specific IgG and IgM antibodies against TOX, RV, CMV, and HSV using enzyme-linked immunosorbent assay (ELISA). The positive rates of IgG and IgM were analyzed by age group and other demographic factors.
Results:
The overall IgG seropositivity rates indicated widespread past exposure to CMV, RV, and HSV, while TOX had a relatively lower prevalence. IgM positivity, indicating recent or active infection, was detected at lower rates but still present, particularly for CMV and HSV. Seropositivity varied with age and showed patterns suggesting the need for targeted education and prevention in younger women.
Conclusion:
TORCH infections are prevalent among women of childbearing age in Wuhu, with CMV and HSV showing high rates of latent infection and a proportion of women at risk of primary infection during pregnancy. Strengthening pre-pregnancy screening and health education is essential to reduce adverse maternal and fetal outcomes.