Changes and analysis of hematological and biochemical indexes in sd rats during feeding period from 2015 to 2017

Abstract

Objective:
To observe and analyze the changes in hematological and biochemical indexes in Sprague-Dawley (SD) rats during the feeding period from 2015 to 2017, providing reference data for laboratory animal health monitoring and experimental research.
Methods:
A total of n SD rats raised under standardized conditions between 2015 and 2017 were selected. At different time points during the feeding period, blood samples were collected to measure hematological parameters (e.g., WBC, RBC, HGB, PLT) and serum biochemical indexes (e.g., ALT, AST, BUN, CRE, TP, ALB). Data were analyzed to assess trends over time and differences between sexes or age groups.
Results:
Hematological and biochemical indexes in SD rats showed dynamic changes during the feeding period. Certain indexes, such as hemoglobin and total protein, gradually increased with age, while others, such as white blood cell count, exhibited fluctuations. Significant differences were observed between male and female rats in several parameters (p < 0.05). The values remained within normal physiological ranges, confirming the health status of the animals.
Conclusion:
Hematological and biochemical indexes of SD rats change with age and sex during the feeding period. Regular monitoring of these parameters is essential to ensure the health of laboratory animals and the reliability of experimental results.