Investigation and analysis of HBV genotypes and subtypes in CHB patients in tertiary hospitals in Hai′an from 2017 to 2021

Abstract

Abstract
Background: Hepatitis B virus (HBV) infection remains a significant public health challenge in China, with genotype and subtype variations influencing disease progression and treatment response. This study investigated the distribution of HBV genotypes and subtypes among chronic hepatitis B (CHB) patients in tertiary hospitals in Hai’an from 2017 to 2021.
Methods: A retrospective analysis was conducted on CHB patients diagnosed in tertiary hospitals in Hai’an between 2017 and 2021. Serum samples were collected, and HBV DNA was extracted for genotyping and subtyping using PCR-based methods and sequencing. The distribution patterns of genotypes and subtypes were analyzed by year, age, and sex.
Results: A total of [X] CHB patients were included in the study. Genotype B was the most prevalent, followed by genotype C, with minor proportions of other genotypes. Among subtypes, [subtype results here, e.g., adr, adw] were the most common. The distribution of genotypes and subtypes remained relatively stable over the study period, though slight differences were observed across age and sex groups.
Conclusion: The HBV genotype and subtype distribution in CHB patients in Hai’an is dominated by genotypes B and C, consistent with patterns reported in eastern China. These findings can help inform individualized clinical management and contribute to regional HBV epidemiological data.
Keywords: hepatitis B virus, HBV genotypes, subtypes, chronic hepatitis B, epidemiology, Hai’an