Analysis of the quality control measures in the laboratory for nucleic acid testing of SARS-CoV-2

Abstract

Abstract
This study evaluates the quality control (QC) measures implemented in laboratories conducting nucleic acid testing for SARS-CoV-2 to ensure accuracy and reliability of test results. Through a comprehensive review of laboratory protocols and analysis of QC data from multiple testing sites, the study identifies key factors influencing test performance, including sample handling, reagent quality, equipment calibration, and personnel training. Results highlight the importance of standardized procedures, internal and external quality assessments, and continuous monitoring to minimize false negatives and positives. Challenges such as variability in test kits and biosafety concerns are discussed. The study provides recommendations for strengthening QC systems, including enhanced staff competency, robust documentation, and implementation of automated quality checks. These measures are critical for maintaining high diagnostic standards and supporting effective COVID-19 control efforts.