Effect of flagellin on the adhesion of Clostridium butyricum to intestinal epithelial cells

Abstract

Abstract
This study investigates the role of flagellin in mediating the adhesion of Clostridium butyricum to intestinal epithelial cells. Using in vitro cell culture models, the adhesion ability of C. butyricum strains with varying flagellin expression levels was assessed. Results indicate that flagellin significantly enhances bacterial adhesion to epithelial cells, likely by facilitating interaction with host cell receptors and contributing to colonization. The study provides insight into the molecular mechanisms underlying C. butyricum’s gut colonization and suggests that flagellin may be a key factor influencing probiotic efficacy and intestinal health. These findings contribute to understanding host-microbe interactions and may inform the development of targeted probiotic therapies.